HGH 191aa
Recombinant Human Growth Hormone 191 amino acid sequence. The gold standard for growth hormone research, identical in structure to naturally produced HGH.
Compound Profile
Pharmaceutical Data Sheet
Mechanism of Action
How HGH 191aa Works
HGH 191aa is structurally and functionally identical to endogenous pituitary growth hormone. Upon binding to the GH receptor (GHR), it triggers dimerization and activation of JAK2 kinase, which phosphorylates STAT5 transcription factors. STAT5 then drives IGF-1 synthesis in liver and peripheral tissues — mediating most of GH's anabolic, lipolytic, and growth-promoting effects.
- Drives skeletal muscle hypertrophy via IGF-1R/PI3K/Akt
- Stimulates bone growth at epiphyseal plates
- Promotes protein synthesis in myocytes
- Mediates 70–90% of GH anabolic effects
- Direct transcription of IGF-1 and IGFBP-3
- Regulates hepatic metabolism and glucose homeostasis
- Controls lipolysis in adipose tissue
- STAT5b drives male-pattern gene expression
- Stimulates lipolysis in adipocytes via cAMP/PKA/HSL
- Promotes fatty acid oxidation for energy
- Counteracts insulin action on fat storage
- Drives anti-obesity metabolic profile
Binding of HGH to GHR causes receptor dimerization, which recruits and activates JAK2 tyrosine kinase. JAK2 phosphorylates STAT5a/b, which translocates to the nucleus and transcribes IGF-1, IGFBP-3, and growth-related genes. Peripheral IGF-1 then acts on muscle, bone, and metabolic tissue receptors for anabolic and lipolytic effects.
Brooks AJ & Waters MJ, Nat Rev Mol Cell Biol (2010): GH receptor signaling mechanisms.
Preclinical Findings
Research Models
Clinical Data
Decades of Clinical Use — GH Deficiency & Body Composition
Somatropin (the FDA-approved recombinant HGH) has been used clinically since 1985. Hundreds of controlled trials document effects on lean mass accrual, fat reduction, and metabolic parameters in GH-deficient adults. Research-grade 191aa is structurally identical.
Molitch ME et al., J Clin Endocrinol Metab (2011): GH replacement in adult GHD.
Systematic review of GH replacement trials
Research Outcomes
Key Research Success Metrics
Safety Profile
Research Safety Notes
- Well-established safety profile from decades of clinical use as Somatropin
- Primary adverse effects: fluid retention, carpal tunnel, joint pain at high doses
- Insulin resistance possible at supraphysiological doses — monitor glucose
- Contraindicated in active malignancy — GH is mitogenic via IGF-1 signaling
- Pituitary feedback suppression with chronic exogenous GH administration
HGH 191aa research compound is structurally identical to Somatropin but intended for laboratory research only. Clinical data cited relates to FDA-approved Somatropin use in GH-deficient patients.
About HGH 191aa
Recombinant Human Growth Hormone 191 amino acid sequence. The gold standard for growth hormone research, identical in structure to naturally produced HGH.
All EVO Labs Research compounds are manufactured to research-grade standards and independently tested by Janoshik Analytical (Prague, est. 2013). The Certificate of Analysis for this compound includes full HPLC chromatography data, mass spectrometry confirmation, net purity percentage, and net content verification.
Research Use Only
This product is strictly for in vitro research and laboratory use only. Not for human or veterinary consumption. By purchasing, you confirm use in a controlled research setting.
