HCG 5000IU
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Human Chorionic Gonadotropin — a 237 amino acid glycoprotein hormone composed of alpha and beta subunits. Studied for its LH-mimetic activity at the LH/hCG receptor (LHCGR) and its central role in hypothalamic-pituitary-gonadal axis research protocols.
Compound Profile
Pharmaceutical Data Sheet
Mechanism of Action
How HCG 5000IU Works
Human Chorionic Gonadotropin is a glycoprotein hormone that binds the shared LH/hCG receptor (LHCGR) on gonadal tissue. Despite being distinct from luteinizing hormone, its structural homology at the α-subunit and affinity at LHCGR allow it to reproduce LH-like downstream signaling, making it a foundational tool for hypothalamic-pituitary-gonadal axis research, steroidogenesis studies, and gonadal function modeling.
- Shared receptor with endogenous LH
- Activates Gs/cAMP/PKA cascade
- Drives StAR-mediated cholesterol transport
- Sustained activation due to longer half-life vs LH
- Studied alongside Kisspeptin in HPG axis research
- Bypasses pituitary to directly stimulate gonadal tissue
- Used in research on axis recovery after suppression
- Supports endogenous steroidogenesis research models
- Upregulates StAR protein expression
- Facilitates mitochondrial cholesterol import
- Stimulates P450scc enzyme activity
- Promotes downstream steroid hormone synthesis
hCG binding to LHCGR activates the Gs-coupled pathway, elevating intracellular cAMP and driving PKA-mediated phosphorylation of StAR (Steroidogenic Acute Regulatory protein). This cascade accelerates cholesterol transport into the mitochondrial inner membrane — the rate-limiting step in gonadal steroid biosynthesis observed across preclinical HPG axis models.
Endocr Rev (2019): LH/hCG receptor signaling and steroidogenesis in gonadal tissue.
Preclinical Findings
Research Models
Clinical Data
Established LHCGR Affinity and HPG-Axis Research Utility
hCG has been characterized across decades of endocrinology literature as a high-affinity LHCGR agonist. Its pharmacokinetic profile (long half-life, sustained receptor activation) makes it one of the most widely used compounds for HPG-axis modeling, gonadotropin signaling research, and LH-mimetic study designs.
Cole LA (2010); hCG Biology, Structure, and Function — Mol Cell Endocrinol.
Cumulative preclinical + pharmacology literature
Research Outcomes
Key Research Success Metrics
Safety Profile
Research Safety Notes
- Extensive pharmacology profile spanning decades of endocrinology research
- Well-characterized glycoprotein — no LD50 concerns at research doses in preclinical models
- Shares receptor with endogenous LH, so no novel receptor liabilities introduced
- Reported preclinical side effects confined to expected on-target steroidogenic activity
- Lyophilized for maximum stability — reconstitute with bacteriostatic water immediately before use
HCG is a research-grade glycoprotein supplied in lyophilized powder form. For research use only. Not intended for diagnostic or therapeutic purposes. Independently verified 99%+ purity.
About HCG 5000IU
Human Chorionic Gonadotropin — a 237 amino acid glycoprotein hormone composed of alpha and beta subunits. Studied for its LH-mimetic activity at the LH/hCG receptor (LHCGR) and its central role in hypothalamic-pituitary-gonadal axis research protocols.
All EVO Labs Research compounds are manufactured to research-grade standards and independently tested by Janoshik Analytical & Kovera Labs. The Certificate of Analysis for this compound includes full HPLC chromatography data, mass spectrometry confirmation, net purity percentage, and net content verification.
Research Use Only
This product is strictly for in vitro research and laboratory use only. Not for human or veterinary consumption. By purchasing, you confirm use in a controlled research setting.
